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KMID : 1038820150180010048
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Pediatric Gastroenterology, Hepatology & Nutrition
2015 Volume.18 No. 1 p.48 ~ p.54
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Liver Transplantation for Metabolic Liver Disease: Experience at a Living Donor Dominant Liver Transplantation Center
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Kim Jun-Suk
Kim Kyung-Mo
Oh Seak-Hee
Kim Hyun-Jin
Cho Jin-Min
Yoo Han-Wook
Namgoong Jung-Man
Kim Dae-Yeon
Kim Ki-Hun
Hwang Shin
Lee sung-Gyu
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Abstract
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Purpose: Metabolic liver disease (MLD) often progresses to life-threatening conditions. This study intends to describethe outcomes of liver transplantation (LTx) for MLD at a living donor-dominant transplantation center where potentiallyheterozygous carrier grafts are employed.
Methods: We retrospectively evaluated the medical records of 54 patients with MLD who underwent LTx betweenNovember 1995 and February 2012 at Asan Medical Center in Seoul, Korea. The cumulative graft and patient survivalrates were analyzed according to patient age, and living or deceased donor LTx. Recurrence of the original diseasewas also investigated.
Results: The post-transplant cumulative patient survival rates at one, five, and 10 years were 90.7%, 87.5% and87.5%, and the graft survival rates were 88.8%, 85.5%, and 85.5%, respectively. There were no differences in thepatient survival rates according to the recipient age, human leukocyte antigen matching, and living or deceaseddonor LTx. There were also no differences in the patient survival rates between the MLD and the non-MLD groupsfor children. Recurrence of the original metabolic disease was not observed in any patient during the follow-up period.
Conclusion: Our results suggest that the living donor-dominant transplantation program is well-tolerated in MLD withoutrecurrence of the original MLD using all types of transplantation.
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KEYWORD
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Metabolic diseases, Liver transplantation, Adult, Child
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